EuroMRD NHL 2026

EuroMRD NHL EQA scheme 2026

Task 1: IG/TR-based RQ-PCR

Within this task, quality assessment for IG/TR based minimal residual disease (MRD) RQ-PCR for non-Hodgkin lymphoma (NHL) is performed. Task 1 deals with correct interpretation of IG/TR RQ-PCR based on real-time quantitative PCR data of 10 patient cases presented as electronic files.

Task 4A: IGH::BLC2 RQ-PCR in Follicular Lymphoma

Task 4A consists of RQ-PCR based MRD quantification of IGH::BLC2 major or minor (MBR or mcr) breakpoints on provided samples, according to the instructions provided by the organizers and the EuroMRD guidelines.

Task 4B: IGH::CCND1 and IGH RQ-PCR in Mantle Cell Lymphoma

Task 4B consists of the analysis of two provided sequences, an IGH::CCND1 translocation and an IGH gene rearrangement. For both targets, a primers/probe combination must be designed and RQ-PCR analysis performed on follow-up (FU) samples, according to the instructions provided by the organizers and the EuroMRD guidelines.

Always combined with the mandatory Task 1, Task 4A is issued for the spring and Task 4B for the autumn EQA round.

Performance evaluation and report

Certificates of participation and performance in EQA rounds will be distributed after the EuroMRD meeting of the same calendar year. Performance criteria of the NHL scheme: a certificate will be provided if at least 75% of points have been received (Task 1+4A, and/or Task 1+4B, respectively), otherwise only a certificate of attendance will be provided for the respective tasks.

After release of the certificates, participants can submit an appeal if they feel that a mistake was made in the assessment of their performance. If applicable, certificates will be adapted based on received appeals.

EQA Educational meeting

During the ESLHO week in November, the annual EuroMRD meeting is organized. At this meeting, the results of all EuroMRD EQA schemes are shown (pseudonymized) and discussed with all EuroMRD participants, in small discussion groups as well as during plenary sessions.

Registration and participation fee

The EuroMRD NHL EQA scheme is only available for participants of the EuroMRD Consortium that are part of the NHL section. The participation fee is € 300, regardless of whether you participate in one or both rounds. In addition, the EuroMRD annual fee is charged once to every EuroMRD participant.

Organization

The NHL EQA scheme is organized by ESLHO (EQA Program Coordinator: Prof. Dr. Jacques J.M. van Dongen) in collaboration with the EuroMRD EQA Committee (NHL scheme lead: Dr. Daniela Drandi). The members of the EuroMRD EQA Committee are participants of the EuroMRD Consortium. The EuroMRD subject-matter experts provide support for:

• Pre-round: Case selection, determination of consensus results

• Post-round: Data analysis, performance evaluation, reporting

Details on the task division can be found below.

Task division